Risk Factors and Patterns of Myocardial Injury in Patients with COVID-19: A Single-Centre Cohort Study

Author:

Javed Muhammad1,Zahid Tehreem2,Ghulam Akbar Nasr-us-Salam1,Alavi Palwasha2,Choudry Ammar Khalid2,Aziz Maliha2

Affiliation:

1. Shifa International Hospital, Islamabad, Pakistan

2. Clinical Research Center, Shifa International Hospital, Islamabad, Pakistan

Abstract

Objective: The primary objective was to compare the risk factors and trends of patients with COVID-19 with and without biochemical evidence of myocardial injury. Secondary objectives were the duration of hospitalisation, admission to an intensive care unit, mode of resuscitation, and use of supplemental O2. Design, and place and duration of study: This retrospective cohort study was conducted at Shifa International Hospitals, Islamabad, Pakistan. The study was conducted from May 2021–May 2022. Methodology: 113 patients admitted with a confirmed diagnosis of COVID-19 and troponin-I investigation were included in the study. Patients were divided into two groups: with and without myocardial injury on admission. Demographics, symptoms, diagnostics, vitals, comorbidities, and outcomes were noted. The χ2 exact test for categorical variables and independent t-test for continuous variables were used. All statistical analyses were performed with SPSS Statistics®, version 26.0 (IBM®, Armonk, New York, USA), with 0.05 as a level of significance. Results: Out of 113 patients, 47 patients (42%) had no myocardial injury on admission. The mean age of the patients was 63 years. Patients with myocardial injury were older, male, and unvaccinated against COVID-19 (p<0.01). No vital signs or presenting symptoms were statistically significant for myocardial injury. A comorbidity of hypertension on admission was suggestive of myocardial damage. Patients with myocardial injury had a higher risk of requiring resuscitation by cardiopulmonary resuscitation or pharmacologic means. Conclusion: Patients with myocardial injury did not have any impact on the composite of secondary outcomes, such as the duration of hospitalisation, admission to an intensive care unit, and use of supplemental O2.

Publisher

European Medical Group

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3