Anti-inflammatory potential of the aqueous extract of Cyamopsis tetragonoloba against the MSU-induced arthritis in female Wistar albino rats

Abstract

Objective: Gout is an acute inflammation with joint swelling and pain. Uric acid plays a major role in causing gouty arthritis. Crystal shaped uric acid was found in the joint fluid at the severe condition. Guar gum is an herbal product with numerous medical benefits and its botanical name is Cyamopsis tetragonoloba. This study aims to find the protective activity of Cyamopsis tetragonoloba against the MSU-induced gouty arthritis in female Wistar albino rats. Methods: The parameters like weight assessment, paw volume, biochemical parameters (urea, uric acid and creatinine), antioxidant activities and histopathological of paw have been analyzed. The animals have been divided into 5 groups as follows 1) normal control, 2) Monosodium Urate Crystal (MSU)-induced on 1st day, 3) MSU-induced and treated with 500 mg of Cyamopsis tetragonoloba, 4) MSU-induced and treated with 1000 mg of Cyamopsis tetragonoloba and 5) MSU-induced and treated with indomethacin. Results: Aqueous extract of Cyamopsis tetragonoloba has shown reduced paw volume, renal markers, lipid peroxidation and acid phosphatase, whereas it raised anti-oxidants levels and diminished the inflammation in rats paw bone. Conclusion: The aqueous seed extract of Cyamopsis tetragonoloba has shown good benefits against MSU-induced gouty arthritis. The molecular studies have to be studied to known this mechanism in treating the inflammation.