Association of microRNA-155 gene polymorphism and the incidence of systemic lupus erythematosus in Iraqi patients

Abstract

An intricate, multisystemic autoimmune disease that affects multiple organs is known as systemic lupus erythematosus, or SLE. Alterations in genetic material contribute to the development of SLE. The present work aims to investigate the association of genetic variants of microRNA-155 (miR-155) that are essential in the pathogenesis of SLE. A case-control study was conducted with40 female patients and 40 healthy individuals as control group who were from the Medical City/Baghdad Teaching Hospital. The molecular study of miR-155 was performed by polymerase chain reaction using uniquely designed primers followed by sanger sequencing the results showed that wild type was present in all 80 samples. This study also detected two SNPs (rs190708267 and rs1547354) under the control group. According to NCBI, the SNPs detected are not related to any disease, but may be protective factors in healthy individuals.