Thrombosis in patients with inherited coagulation factor disorders

Abstract

Introduction.  The main manifestation of hereditary coagulopathies is bleeding, but patients with these diseases are not protected from thrombotic complications.Aim: to evaluate the frequency and nature of thrombotic complications in various bleeding disorders.Main findings.  In some bleeding disorders, such as von Willebrand disease, thromboses are extremely rare, while in others, such as dysfibrinogenemias, thrombosis is one of the key manifestations. For hemophilia A, there has recently been a significant expansion of treatment options. The use of some new drugs has already been associated with thrombotic complications in the clinical trial phase.