Affiliation:
1. Research Institute of Pediatric Oncology and Hematology, National Medical Research Center of Oncology named after N.N. Blokhin of the Ministry of Health of Russia
2. Republican Pediatric Clinical Hospital of Ministry of Health of Republic of Tatarstan
Abstract
Introduction. Identical twins are a unique model that can be used to assess the concordance of various diseases, including acute leukemia. It should be noted that acute leukemia is characterized with high concordance in cases of monovular twins or placentas adhesion, which confirms the model of development of this disease in the prenatal period.Aim — to present a clinical case of successful diagnosis and treatment of acute lymphoblastic leukemia in identical twins.Main findings. Clinical cases demonstrate the development of common-variant of B-cell precursor acute lymphoblastic leukemia in identical twins with three months interval. The disease course of one of the brothers was characterized by relapses, but treatment with highly effective protocols usage achieved 15-year remission without allogeneic stem cell transplantation. In case of second twin, disease-free life expectancy is 22 years.
Publisher
National Medical Research Center of Hematology of the Ministry of Health of the Russian Federation