Depletion of praziquantel from gilthead sea bream (Sparus aurata) muscle plus skin

Abstract

The depletion pattern of praziquantel (PZQ) from gilthead sea bream (Sparus aurata) muscle plus skin was determined in this study. Fish averaging 100.2 ± 17.7 g and kept at 25oC received a PZQ-dosing of 150 mg/kg fish for 3 days. Muscle plus skin of each of ten fish were collected on days 1, 2, 3, 4, and 6 days post-treatment. Depletion of PZQ from the edible gilthead sea bream tissues was rapid, as its concentrations declined to 0.04 μg/g as early as 24 h post-treatment, while was undetectable at 72 h. This information confirms the fact that PZQ is depleted fast from farmed animals including fish such as the gilthead sea bream and its levels in edible tissues failed below the detection limit in approximately 75 dd.