Ketamine or propofol anesthesia in dogs: how do they affect cytokines, antioxidants and neutrophil functions?

Author:

GUZEL OzlemORCID,Sevim Gulsen,Aydin Kaya Didar,Sezer Duygu,Erek Mert,Esen Gursel Feraye,Atmaca Gizem,Demirtas Berjan,Matur Erdal

Abstract

The objective of the study is to investigate the effects of ketamine and propofol on cytokines, antioxidant defense system, and neutrophil functions in dogs. A total of 24 dogs were used. Dogs were divided into two groups as ketamine and propofol. The ketamine group received ketamine (5 mg/kg) intravenously while the propofol group received propofol (4 mg/kg) intravenously. Blood samples were collected before sedation and 30 minutes after induction. Serum antioxidant and cytokine levels were analyzed and neutrophil functions were determined. Respiration rate, serum malondialdehyde, IL-4, IL-6 levels, and phagocytic and chemotaxic activity of neutrophils were decreased (P=0.001, P=0.010, P=0.014, P=0.039, P=0.008, and P=0.037, respectively), oxygen saturation were increased (P=0.025) in the ketamine group. Serum IL-6 and IFN-γ level were decreased (P=0.015 and P=0.032 respectively), chemotactic activity of neutrophils were increased (P=0.049) in propofol group. The administration of ketamine was found to have a positive effect both on the antioxidant system and the neutrophil. On the other hand, positive and negative effects of propofol on different parts of the immune system were observed. Therefore, the results should should be taken into account when designing an anesthesia protocol for dogs to predict possible defense system reactions during the postoperative period.

Publisher

National Documentation Centre (EKT)

Subject

General Veterinary

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3