The effect of hyperbaric oxygenation on the state of blood cells in children with inflammatory bowel diseases

Abstract

The aim of this work is to determine changes in erythrocyte and platelet indices during standard therapy for inflammatory bowel diseases (IBD) in children and combination with hyperbaric oxygenation (HBO). Materials and methods. We used the blood of 147 children of both genders aged 6-17 years with IBD: 76 - with Crohn’s disease (CD), 71 - with ulcerative colitis (UC). The complex of treatment for patients (16 with CD, 11 with UC) included HBO therapy, which was carried out in a single air-oxygen pressure chamber «BaroOx 1.0». The course consisted of 5-8 daily sessions in the 1.3-1.4 atm regime for 40 minutes. The number of platelets and blood cell indices in all patients were determined: MCV, RDW, MCH, MCHC, MPV, PDW. Results. IBD in children is characterized by a significant increase in platelet count, a decrease in MCV and MPV, and an increase in RDW and PDW. The use of HBO in IBD treatment promotes an increase in MCV, MCHS and a tendency to decrease the number of platelets. Conclusion. The patterns of changes in the qualitative and quantitative characteristics of blood cells that we have established indicate that the use of HBO to the standard treatment protocol for IBD in children contributes to the correction of the identified disorders.