Locoregional Therapy for Early and Locally Advanced Breast Cancer

Abstract

Objective: The objective of this article is to conduct a comprehensive review of recent advances in locoregional therapies for early and locally advanced breast cancer, emphasizing the integration of these approaches into comprehensive treatment plans. Initially, this study explores contemporary findings related to surgical techniques, radiation therapy, and the integration of systemic treatments, such as targeted therapies and chemotherapy, as part of a cohesive treatment strategy.   Theoretical Framework: Breast cancer remains a significant public health issue, with locoregional therapy playing a critical role in the management of early and locally advanced stages of the disease. The evolution of treatment strategies reflects a deepening understanding of the disease's biological behavior and the necessity for tailored therapeutic approaches.   Method: A systematic review was conducted using major scientific databases to collect relevant articles on recent advances in locoregional therapy for breast cancer, from surgical innovations to advanced radiation techniques. Specific keywords were used to identify studies that address new findings and interdisciplinary approaches, facilitating the synthesis of effective strategies and the identification of gaps in current research.   Results and Discussion: Recent research has improved surgical precision and radiation delivery techniques, reducing side effects and enhancing treatment efficacy. Innovations in intraoperative radiation and the growing use of neoadjuvant therapies offer promising results, optimizing tumor control and preserving patient quality of life. However, challenges remain in achieving consistent results across different patient populations, underscoring the need for personalized treatment plans tailored to individual patient characteristics and tumor biology.