Diabetic Nephropathy as a Result of Uncontrolled Hyperglycemia

Abstract

Objective: to investigate the relationship between uncontrolled hyperglycemia and the development of diabetic nephropathy.   Methods: Integrative review of the literature, carried out in June 2024, in the virtual databases Virtual Health Library, Medical Literature Analysis and Retrieval System Online and Google Scholar using the descriptors “Diabetic Nephropathies”, “Glomerular Filtration Rate”, “Hyperglycemia” and “Diabetes Mellitus”, as well as “Diabetic Nephropathies”, “Glomerular Filtration Rate”, “Hyperglycemia” and “Diabetes Mellitus” selected by DeCS and MeSH Descriptors, related to the Boolean operator AND in all databases.   Results and Discussion: after completing the methodological procedures, 12 articles available on the VHL Portal, in the PubMed, VHL and Google Scholar databases were selected, which show that diabetic nephropathy is a serious and common complication of diabetes mellitus, characterized due to the progressive impairment of renal function, being one of the main causes of chronic kidney disease and terminal renal failure worldwide. The development of diabetic nephropathy is linked to glycemic control, with chronic hyperglycemia being a crucial factor in the pathogenesis of this condition.   Final Considerations: strict control of blood glucose and blood pressure, combined with pharmacological interventions and lifestyle modifications, constitutes the basis of effective management of diabetic nephropathy.