ALKYL-1H-BENZO[D]IMIDAZOLE SYNTHESIS FROM ALKYL BROMIDES AND 1,2-BENZENEDIAMINES BY A MILD DOMINO REACTION

Abstract

A method was implemented for synthesis of 2-alkyl-1H-benzo[d]imidazole derivatives in dry medium. Starting reagents, 1,2-diaminobenzene derivatives and primary alkyl halides using pyridine N-oxide is converted into benzimidazoles. The protocol does not use catalyst and solvent. Simplicity and easy work-up are the important advantages of the method.