Evaluating the Efficacy of Non-Invasive Mechanical Ventilation in Managing Acute Exacerbations of COPD in a Tertiary Care Centre Hapur Uttar Pradesh

Abstract

Background- COPD is currently ranked among the top 3 rd.leading leading cause of mortality globally, with ninety percent of .the. mortality concentrated .in under developed and developing nations COPD poses a huge healthcare issue that is either preventable or treatable (COPD) is a bigger cause of long-term illness and mortality globally. Numerous patients endure this condition for extended periods and experience premature death as a result of the disease itself or its associated complications. The implementation and extensive adoption of non- invasive mechanical ventilation (NIMV) have significantly transformed the management and survival outcomes for patients experiencing exacerbations of chronic obstructive pulmonary disease (COPD). This observational study aims to evaluate the outcomes of NIMV in AECOPD within our hospital setting.  Objective:- To monitor and analyze the outcomes of patients managed with .non-.invasive mechanical. ventilation, specifically focusing on the necessity for endo-tracheal intubation, .mechanical .ventilation, & improvements in .A.B.G levels & vital signs.  Material and Method:- This observational study was conducted on 100 patients with COPD. This study observed patients who underwent NIMV receiving pharmaceutical therapy for AECOPD. The evaluation of patients were depend upon clinical improvements, including reductions in .respiratory .rate and .heart .rate, as well as enhancements in arterial blood gas levels after initiating NIMV.  Results:- The primary outcome assessed was the need for intubation. Among the 100 patients, 88 (88%) showed an improved outcome, including enhancements in pH, PaCO2, respiratory rate, and heart rate after the first and fourth hours of starting NIMV. The study found a statistically significant difference between these values, indicating the efficacy of NIMV in managing acute exacerbations of COPD  Conclusion:- The study concludes that Non-Invasive Mechanical Ventilation (NIMV) shows promise as a treatment approach for managing acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD). Timely implementation of NIMV results in rapid and significant change in arterial blood gas levels, thereby reducing the needed for endo-tracheal intubation in these patients.