An Overview on Stimuli Sensitive Drug Delivery System

Abstract

Stimuli-sensitive systems are a state of reactivity to sensory stimulation or excitability. These systems respond to changes in the body’s physiology due to environmental factors such as temperature, enzymes, glucose, magnetic fields, redox reactions, ions, and more. They are particularly useful for the controlled and sustained delivery of drugs in the body. Controlled drug delivery has become a standard criterion in modern pharmaceutical product design, with ongoing intensive research aimed at achieving a superior drug product characterized by effectiveness, reliability, and safety. These stimuli-sensitive systems are employed in various forms for different purposes, including parenteral, ocular, peroral, rectal, vaginal, nasal, dermal, and transdermal drug delivery. This study focuses on the latest advancements in stimuli-sensitive drug delivery systems, aiming to address the limitations of traditional therapeutic methods. The goal is to achieve targeted drug release in specific areas using various endogenous and exogenous stimuli. This allows for personalized and patient-centric treatment strategies. The development of stimuli-sensitive drug delivery systems remains a significant human endeavor for successful drug delivery, given the various shortcomings of existing conventional systems. To overcome these limitations, various stimuli-sensitive drug delivery systems (DDSs) have been developed in recent years