HIV-Associated Immune Dysfunction and Hematological Abnormalities: A Detailed Examination of Pathophysiology and Clinical Implications

Abstract

Human Immunodeficiency Virus (HIV) exerts profound effects on both the immune and hematological systems, leading to a range of complications that significantly influence patient outcomes and quality of life. This review examines the intricate interplay between HIV infection, immune system dysfunction, and hematological abnormalities. We detail the mechanisms underlying these complications, including the direct impact of HIV on CD4+ T lymphocytes, the persistent immune activation observed despite antiretroviral therapy (ART), and the diverse etiologies of HIV- associated anemia, thrombocytopenia, and leukopenia. Additionally, we address the clinical implications of these issues, emphasizing their role in disease progression and the current therapeutic approaches. This review highlights the imperative for continued research and the advancement of integrated care strategies to enhance long-term outcomes for individuals living with HIV.