Preparation and Identification of Magnetic Iron Nanoparticle based on a Natural Hydrogel and its Performance in Targeted Drug Delivery

Abstract

Billions of dollars are spent annually in the world to treat and investigate problems caused by drug side effects. According to the estimates of health researchers, about 40%of people who take medicine suffer from side effects. In this way, the necessity of using a targeted system in order to deliver medicine to the desired place without damaging healthy tissues is felt more than ever. In recent years, targeted drug delivery systems based on nanoparticles have received much attention. Meanwhile, the use of natural polymers is more suitable for various purposes in drug delivery systems in terms of indicating greater biological compatibility with the body and being non-toxic.In this research, the natural hydrogel extracted from the seeds of the Plantago ovata, which is loaded on the bed of magnetic iron nanoparticles, was used to entrap the drugmefenamic acid. In order to achieve this goal, at the beginning, magnetic iron nanoparticles were prepared by co-precipitation method using iron (II) and iron (III) oxides, and then a coating of silica was created on its surface, then the hydrocolloid of Plantago ovata was extracted from its seed, in order to connect the magnetite nanoparticles and the polymer extracted from the Plantago ovata, the surface of both components was modified by vinyl-functional groups. Next, radical polymerization under heat was used to connect the particles and trap the drug, after that the release of the drug from the polymer capsule was checked by UV-Vis device. Before examining the drug release, the resulting product was identified by FT-IR, XRD, VSM, DLS, TGA, SEM analysis. Therefore, the obtained results indicated that the natural polymer was correctly loaded on the desired magnetic substrate and the drug mefenamic acid was trapped inside the hydrogel networks and polymer capsule. Therefore, the drug can be directed in a controlled and targeted manner by the magnetic field, and the release of the drug was done well and at an acceptable speed.