Simultaneously Estimation of Multicomponent Containing Formulation by using UV-Spectroscopy [Aspirin-Atorvastatin]

Abstract

The market is currently offering a wide range of combination dose forms, and the quantity is growing daily. Due to their improved potency, various actions, speedier relief, fewer side effects, and higher patient acceptability, these multicomponent formulations are becoming more and more popular. It is therefore intended that these formulations satisfy all requirements for their efficacy, safety, and quality. This is only feasible if many analytical methods are available to determine them. When doing a simultaneous multicomponent analysis, various UV spectrophotometric techniques are applied.These techniques rely on logging and processing absorption spectra computationally. The various techniques covered in this review include the use of simultaneous equations, derivative spectrophotometry, mean centring of the ratio spectra, absorption factor method, double divisor ratio spectra derivative method, successive ratio derivative spectra, Q-absorbance ratio method, isosbestic point method, absorpitivity factor method, dual wavelength method, mean centring of the ratio spectra, and multivariate methods. A synopsis of the theories and a few uses for these techniques are given.