Comparative evaluation about the efficacy of the use of variable concentrations of Epinephrine in Tumescent solution for control of bleeding in patients with abdominal liposuction

Abstract

Introduction: The use of epinephrine for controlling the blood loss has gained out in many dermatological surgeries; however, its use in liposuction has not been studied. In this regard, we aimed to figure out the effectiveness of using epinephrine in tumescent solution during liposuctions surgery. Material and Methods: In this study we present a prospective, double-blind, nonrandomized study evaluating the effects of adding epinephrine to tumescent solution intra-operative in patients undergoing liposuction. Thirty-six patients including 6 males and 29 females undergoing liposuction were divided into two groups. In case group we use 1-1.4 mg/L epinephrine (based on the location of surgery) in tumescent solution; and control group did not receive epinephrine. Lab data such as hemoglobin and hematocrit as well as clinical data including blood pressure and heart rate were recorded before, after 1h and 6h of liposuction.  Results: In this study, we observed that both case and control group faced a significant dropped in their hemoglobin and hematocrit; however, the decrement was significant lower in case group. In addition, both groups had a stable hemostasis after 1h and 6h of surgery. In this regard, we did not observe any significant difference between heart rate and blood pressure of two groups. Conclusion: The results of this study suggest that using epinephrine as vasoconstriction agent in tumescent solution might decrease the rate of bleeding and increase the chance of stable hemostasis both during and after abdominal liposuction.