MicroRNA-5196 as an Accurate Biomarker of Disease Activity and Response to Treatment in Rheumatoid Arthritis
-
Published:2024-04-30
Issue:2
Volume:10
Page:
-
ISSN:2413-0516
-
Container-title:Journal of Contemporary Medical Sciences
-
language:
-
Short-container-title:J. Contemp. Med. Sci.
Author:
Jassim Hadeer Hamid,Ahmed Abdul-Hassan Abbas ,Mohammed Hadi-Alosami
Abstract
Objective:
Methods: One hundred patients divided into two groups’ 50 responders and 50 non responders with 50 healthy individuals were studied. The serum expression ofmiRNA-5196 was detected by using real-time polymerase chain reaction.
Results: miRNA-5196 expression was significantly higher in rheumatoid arthritis patients versus control group P <0.05. Sub-group of patients into responders and non-responders showed that miRNA-5196 expression higher in non-responders than responders.miRNA-5196 expression related with response to TNF-α inhibitor and disease activity in patients with rheumatoid arthritis.
Conclusion: miRNA-5196 may consider as a valid target for monitoring progression of RA disease and response to TNF-α inhibitor therapy.
Publisher
Naba'a Al-Hayat Foundation for Medical Sciences and Health Care