Association between Microalbuminuria and MYH9 Gene Polymorphisms in Hypertensive Iraqi Patients with Metabolic Syndrome

Abstract

Objective: The presented work aimed to study the correlation between micro-albuminuria and MYH9 (T˃C) (rs3752462) gene polymorphisms in metabolic syndrome of Iraqi patients. Methods: This study was a cross - sectional study. Sample size was 140 persons of both gender selected randomly between 1st , April. , 2019 to 15th, Aug. , 2020. They are divided into two groups, 80 with metabolic syndrome patients and 60 with control groups subdivided into another two groups: 30 persons with obese and 30 persons without obese. The distribution of sample according to the gender, the number of males had metabolic syndrome were (47) and female (33), but in obese healthy control the number of males were (19) and female (11), while in non-obese healthy control the number of males were (15) and female (15). The age groups were ranged between (40-60) years. Typing of MYH9 was performed by refractory mutation system-polymerase chain reaction (ARMS-PCR). The current study was performed to investigate the SNPs that affected MYH9 gene which was (T˃C) (rs3752462). Results: There was a significant difference between blood sugar, HbA1c, total cholesterol, TG, VLDL-C, LDL-C, blood urea, micro-albuminuria, BMI and HOMA-IR in metabolic syndrome patients as compared with healthy control groups (P ≤ 0.01). The significant result (P ≤ 0.01) were appeared between (TT) for MYH9 genotype patients and obese control with biochemical parameters (Blood glucose, HbA1c, TC, TG, VLDL-C and LDL-C). The correlation between (TT) SNP for MYH9 genotype patients and non - obese control with biochemical parameters is significant result (P ≤ 0.01 and P ≤ 0.05)  (Blood glucose, HbA1c, insulin, TC, TG, VLDL-C, LDL-C, urea and micro-albuminuria). The significant result (P ≤ 0.01 and P ≤ 0.05) were appeared between (CT) for MYH9 genotype patients and obese control with biochemical parameters (Blood glucose, HbA1c, TC, TG and VLDL-C) respectively. Conclusion: There is a significant difference between blood glucose, HbA1c, total cholesterol, TG, VLDL-C, LDL-C, blood urea, micro-albuminuria, BMI and HOMA-IR in metabolic syndrome patients and healthy control groups (P ≤ 0.01). Also a significant result (P ≤ 0.01) obtained between (TT) for MYH9 genotype patients and obese and non-obese control with some biochemical parameters. (P ≤ 0.01 and P ≤ 0.05). The significant result (P ≤ 0.01 and P ≤ 0.05) appear between (CT) for MYH9 genotype patients and obese control with some biochemical parameters.