LEP and LEPR Polymorphisms Influences Anthropometric Outcome in Response to 8 Weeks of Combined Training in Obese boys

Abstract

Background: Weight loss can be influenced by variants of the leptin-encoding genes in obese individuals. The purpose of the present study was to investigate whether LEP19 G>A and LEPR 668 A>G polymorphisms, would influence the effect of an 8-week combined aerobic and resistance training. Methods: Thirty obese boys (BMIz>+2) aged 11-13 (12.66±0.47) were recruited from three middle schools in Quchan. The changes in body composition parameters and metabolic factors in response to 8-weeks combined aerobic and resistance training program were analyzed regarding LEP and LEPR polymorphism. DNA was extracted from cheek cells donated by the 30 participants and genotyping was carried out using PCR. Results: Our results suggest that carriers of rs2167270G allele and rs1137101A allele were characterized by a greater reduction in body mass and WHR (P< 0.05). Also, a significant decrease was observed in leptin levels in carriers of rs2167270G allele after the training program (P=0.031). Moreover, the LEP and LEPR polymorphisms were associated with changes in lipid profile in response to training. Conclusion: In response to 8 weeks of regular physical activity, obese boys with G (rs2167270) and A (rs1137101) alleles had the best likelihood of losing weight which was associated with a decrease in body mass, fat mass (%), WHR and leptin concentrations.