Affiliation:
1. Plant Gene Expression Center, United States Department of Agriculture-Agricultural Research Service, Albany, California, 94710 and Department of Plant and Microbial Biology, University of California, Berkeley, 94720
Abstract
Abstract
In eukaryotes, Polycomb group (PcG) and trithorax group (trxG) factors oppositely regulate gene transcription during development through histone modifications, with PcG factors repressing and trxG factors activating the expression of their target genes. Although plant trxG factors regulate many developmental and physiological processes, their downstream targets are poorly characterized. Here we use transcriptomics to identify genome-wide targets of the Arabidopsis thaliana trxG factor ULTRAPETALA1 (ULT1) during vegetative and reproductive development and compare them with those of the PcG factor CURLY LEAF (CLF). We find that genes involved in development and transcription regulation are over-represented among ULT1 target genes. In addition, stress response genes and defense response genes such as those in glucosinolate metabolic pathways are enriched, revealing a previously unknown role for ULT1 in controlling biotic and abiotic response pathways. Finally, we show that many ULT1 target genes can be oppositely regulated by CLF, suggesting that ULT1 and CLF may have antagonistic effects on plant growth and development in response to various endogenous and environmental cues.
Publisher
Oxford University Press (OUP)
Subject
Genetics(clinical),Genetics,Molecular Biology
Reference80 articles.
1. Two Arabidopsis homologs of animal trithorax genes: a new structural domain is a signature feature of the trithorax family.;Alvarez-Venegas;Gene,2001
2. Methylation patterns of histone H3 Lys 4, Lys 9 and Lys 27 in transcriptionally active and inactive Arabidopsis genes and in atx1 mutants.;Alvarez-Venegas;Nucleic Acids Res.,2005
3. ATX-1, an Arabidopsis homolog of trithorax, activates flower homeotic genes.;Alvarez-Venegas;Curr. Biol.,2003
4. The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes.;Alvarez-Venegas;Proc. Natl. Acad. Sci. USA,2006
5. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes.;Baumbusch;Nucleic Acids Res.,2001
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献