Affiliation:
1. Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853
Abstract
Abstract
Several recent studies have suggested that F1 hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.
Publisher
Oxford University Press (OUP)