Hardy-Weinberg Testing of a Single Homozygous Genotype-Reference-Cited by-同舟云学术

Hardy-Weinberg Testing of a Single Homozygous Genotype

Published:2005-07-01 Issue:3 Volume:170 Page:1439-1442
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Chen John J¹,Duan Tao¹,Single Richard²,Mather Kristie³,Thomson Glenys³

Affiliation:

1. Department of Preventive Medicine, State University of New York, Stony Brook, New York 11794

2. Medical Biostatistics, University of Vermont, Burlington, Vermont 05405

3. Department of Integrative Biology, University of California, Berkeley, California 94720

Abstract

Abstract No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. χ2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/170/3/1439/42067541/genetics1439.pdf

Reference16 articles.

1. The Variance for the Disequilibrium Coefficient in the Individual Hardy-Weinberg Test

2. Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, AND DPB1) loci in 26 human ethnic groups

3. Enhanced PCR amplification of VNTR locus D1S80 using peptide nucleic acid (PNA)

4. Heterogeneous mutation processes in human microsatellite DNA sequences

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