Heterochromatin Position Effects on Circularized Sex Chromosomes Cause Filicidal Embryonic Lethality in Drosophila melanogaster-Reference-Cited by-同舟云学术

Heterochromatin Position Effects on Circularized Sex Chromosomes Cause Filicidal Embryonic Lethality in Drosophila melanogaster

Published:2014-04-01 Issue:4 Volume:196 Page:1001-1005
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Ferree Patrick M¹,Gomez Karina¹,Rominger Peter¹,Howard Dagnie¹,Kornfeld Hannah¹,Barbash Daniel A²

Affiliation:

1. W. M. Keck Science Department, Claremont McKenna, Pitzer, and Scripps Colleges, Claremont, California 91711

2. Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853

Abstract

Abstract Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitive sequences can be incompatible with one another in cis. The lethal phenotype also bears a remarkable resemblance to a case of interspecific hybrid lethality.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/196/4/1001/42120858/genetics1001.pdf

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