Degradation of Specific Nuclear Proteins Occurs in the Cytoplasm in Saccharomyces cerevisiae-Reference-Cited by-同舟云学术

Degradation of Specific Nuclear Proteins Occurs in the Cytoplasm in Saccharomyces cerevisiae

Published:2014-05-01 Issue:1 Volume:197 Page:193-197
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Chen Li¹,Madura Kiran¹

Affiliation:

1. Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey 08854

Abstract

Abstract The ubiquitin/proteasome system has been characterized extensively, although the site of nuclear substrate turnover has not been established definitively. We report here that two well-characterized nuclear proteins are stabilized in nuclear export mutants in Saccharomyces cerevisiae. The requirement for nuclear export defines a new regulatory step in intracellular proteolysis.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/197/1/193/42188000/genetics0193.pdf

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