Point Mutation Rate of Bacteriophage ΦX174-Reference-Cited by-同舟云学术

Point Mutation Rate of Bacteriophage ΦX174

Published:2009-10-01 Issue:2 Volume:183 Page:747-749
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Cuevas José M¹,Duffy Siobain²,Sanjuán Rafael¹

Affiliation:

1. Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departamento de Genética, Universitat de València, 46071 València, Spain and

2. Department of Ecology, Evolution and Natural Resources, Rutgers University, New Brunswick, New Jersey 08901

Abstract

Abstract The point mutation rate of phage ΦX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0 × 10−6 substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying in DNA-based microorganisms).

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/183/2/747/42175307/genetics0747.pdf

Reference26 articles.

1. Antioxidant survey to assess antagonism to redox stress using a prokaryotic and an eukaryotic system

2. The φX174 Protein J Mediates DNA Packaging and Viral Attachment to Host Cells

3. Distribution of Spontaneous Mutants and Inferences about the Replication Mode of the RNA Bacteriophage φ6

4. An analysis of the clone size distribution of ΦX174 mutants and recombinants

5. A constant rate of spontaneous mutation in DNA-based microbes.

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