Autophagy Genes unc-51 and bec-1 Are Required for Normal Cell Size in Caenorhabditis elegans-Reference-Cited by-同舟云学术

Autophagy Genes unc-51 and bec-1 Are Required for Normal Cell Size in Caenorhabditis elegans

Published:2007-09-01 Issue:1 Volume:177 Page:655-660
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Aladzsity István¹,Tóth Márton L¹,Sigmond Tímea¹,Szabó Emese¹,Bicsák Bertalan¹,Barna János¹,Regős Ágnes¹,Orosz László¹,Kovács Attila L²,Vellai Tibor¹

Affiliation:

1. Department of Genetics, Eötvös Loránd University, Budapest, Hungary and

2. Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, H-1117 Hungary

Abstract

Abstract Here we show that in the nematode Caenorhabditis elegans mutational inactivation of two autophagy genes unc-51/atg1 and bec-1/atg6/beclin1 results in small body size without affecting cell number. Furthermore, loss-of-function mutations in unc-51 and bec-1 suppress the giant phenotype of mutant animals with aberrant insulin-like growth factor-1 (insulin/IGF-1) or transforming growth factor-β (TGF-β) signaling. This function for unc-51 and bec-1 in cell size control and their interaction with these two growth modulatory pathways may represent a link between the hormonal and nutritional regulation of cell growth.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/177/1/655/42089060/genetics0655.pdf

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