Site-Specific Amino Acid Frequency, Fitness and the Mutational Landscape Model of Adaptation in Human Immunodeficiency Virus Type 1-Reference-Cited by-同舟云学术

Site-Specific Amino Acid Frequency, Fitness and the Mutational Landscape Model of Adaptation in Human Immunodeficiency Virus Type 1

Published:2006-11-01 Issue:3 Volume:174 Page:1689-1694
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

da Silva Jack¹

Affiliation:

1. School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia

Abstract

Abstract Analysis of the intensely studied HIV-1 gp120 V3 protein region reveals that the among-population mean site-specific frequency of an amino acid is a measure of its relative marginal fitness. This surprising result may arise if populations are displaced from mutation–selection equilibrium by fluctuating selection and if the probability of fixation of a beneficial amino acid is proportional to its selection coefficient.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/174/3/1689/42085195/genetics1689.pdf

Reference39 articles.

1. A Robust Measure of HIV-1 Population Turnover Within Chronically Infected Individuals

2. Causes of HIV diversity

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