Segmental Duplications Contribute to Gene Expression Differences Between Humans and Chimpanzees-Reference-Cited by-同舟云学术

Segmental Duplications Contribute to Gene Expression Differences Between Humans and Chimpanzees

Published:2009-06-01 Issue:2 Volume:182 Page:627-630
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Blekhman Ran¹,Oshlack Alicia²,Gilad Yoav¹

Affiliation:

1. Department of Human Genetics, University of Chicago, Chicago, Illinois 60637 and

2. Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3052

Abstract

Abstract In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/182/2/627/42171693/genetics0627.pdf

Reference20 articles.

1. Recent Segmental Duplications in the Human Genome

2. Gene Regulation in Primates Evolves under Tissue-Specific Selection Pressures

3. Repetitive and Non-Repetitive DNA Sequences and a Speculation on the Origins of Evolutionary Novelty

4. Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution

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