A Statistical Multiprobe Model for Analyzing cis and trans Genes in Genetical Genomics Experiments With Short-Oligonucleotide Arrays-Reference-Cited by-同舟云学术

A Statistical Multiprobe Model for Analyzing cis and trans Genes in Genetical Genomics Experiments With Short-Oligonucleotide Arrays

Published:2005-11-01 Issue:3 Volume:171 Page:1437-1439
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Alberts Rudi¹,Terpstra Peter¹,Bystrykh Leonid V²,de Haan Gerald²,Jansen Ritsert C¹

Affiliation:

1. Groningen Bioinformatics Centre (GBiC), Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, 9751 NN, Haren, The Netherlands and

2. Department of Cell Biology, Section of Stem Cell Biology, University Medical Centre Groningen, University of Groningen, Groningen, 9713 AV, The Netherlands

Abstract

Abstract Short-oligonucleotide arrays typically contain multiple probes per gene. In genetical genomics applications a statistical model for the individual probe signals can help in separating “true” differential mRNA expression from “ghost” effects caused by polymorphisms, misdesigned probes, and batch effects. It can also help in detecting alternative splicing, start, or termination.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/171/3/1437/42068064/genetics1437.pdf

Reference13 articles.

1. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

2. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'

3. WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior

4. Cis-acting expression quantitative trait loci in mice

5. affy--analysis of Affymetrix GeneChip data at the probe level

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