Infertility is the inability of a couple to produce a pregnancy after 1 year carry out regular sexual intercourse and not using contraception. To determine the factors associated with the incidence of infertility in women of childbearing age in the General Hospital Sawerigading Palopo 2016. This study was an analytical survey with cross sectional study design. The population in this study were all women of childbearing age who came medical check up in Palopo Sawerigading Hospital from March to June, 2016 as many as 240 people. 70 subjects were selected by purposive sampling technique. The data was processed by the statistical program (SPSS) version 20 for windows. Data were analyzed by Chi-Square test using Yates Correction and Pearson Chi-Square test. There is relationship between the work with the incidence of infertility in women of childbearing age p = 0.047 (p <0.05). There is relationship between knowledge and the incidence of infertility in women of childbearing age p = 0.018 (p <0.05). There is relationship between nutritional status and the incidence of infertility in women of childbearing age p = 0.011 (p <0.05). No relationship of age and nutritional status and the incidence of infertility in women of childbearing age in the RSU Sawerigading Palopo 2016.