A Review on Poly-Lactic-Co-Glycolic Acid as a Unique Carrier for Controlled and Targeted Delivery Drugs

Abstract

In regulated and targeted drug distribution, biodegradable polymers have played a significant portion. Poly-lactic-co-glycolic acid (PLGA) has been an important desirable polymer in tissue engineering to meet a new drug delivery system. PLGAs, show a broad spectrum of erosion cycles and have tuning mechanical characteristics. Poly-lactic-co-glycolic acid (PLGA) has been the most successful polymeric biomaterial for use in controlled drug delivery systems. PLGA has been extensively studied, in particular, in the production of equipment for controlled distribution in industrial and research applications of small molecules, protein, and other macromolecules. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. PLGA has many properties such as controlled and sustained release, low cancerinducing, long-standing biomedical applications, biocompatibility with tissues and cells, and prolonged residence time. It is otherwise called as 'Smart Polymer' because improvements are fragile to conduct PLGA that has been widely examined in industrial and academic applications to produce instruments for the target delivery of tiny molecular drugs, proteins, and other large molecules. An introduction about the chemistry, physicochemical properties, manufacturing techniques of the devices, toxicity, and the reason influencing their decrease and release of the drug was given in the present study. Mathematical modelling is a useful tool for identifying, characterizing, and predicting the mechanisms of controlled release. Mathematical modelling applied against the target from PLGA – the devices has been clarified by discussing in the review, by explaining the underlying mathematical models and how this is used. KEY WORDS Biodegradable Polymers, PLGA, Biodegradability, Macromolecules