Association of Risk Factors, Frequency and Outcomes of ST-Elevation Segment in MI with Patients' Birth-Month; Data from a Cohort Study in Western Iran

Abstract

BACKGROUND Given newly debates on the association of birth-month with various diseases, we investigated the association of patients' birth-month with a burdensome lethal disease, ST-elevation myocardial infarction (STEMI). METHODS The data comes from an ongoing cohort-registry conducted on patients with STEMI registered to a mega cardiovascular hospital, in Western Iran (2016 - 2019). Baseline and follow-up data were collected using the European observational registry program (EORP) case report form, through interviewing eligible patients and reviewing their medical records. The quality of data as well as ethics considerations has been approved by EORP and Kermanshah University Medical Sciences (KUMS) Ethics Committees. RESULTS Among 2341 patients (81.5 % male) analysed, the peak of event [myocardial infarction (MI)] was 10 am followed by 8 pm. Their mean age (± SD) was 60.34 ± 12.40 years, minimum 19 years and maximum 96 years. March was significantly more frequent birth-month (16.4 %) (p < 0.001). Nevertheless, in terms of MI incidence, no significant variation was found between 12 months of a year, as well as the four seasons. The most common risk factors were smoking, hypertension, hypercholesterolemia and diabetes. About 3.8 % (n = 90) died in hospital (23 women). More than 6 % of patients expired during the first year of follow up. Although birth- month of 18.89 % (n = 17) of those expired was March, the difference was not significant (p = 0.025). CONCLUSIONS Among 12 months, March was highly significant common birth-month among patients with STEMI; however, this birth-month was not significantly associated with MI frequency of MI risk factors and/or a worse outcome. KEY WORDS Birth Month, Acute Myocardial Infarction, Heart Attack, Risk Factors, Outcomes