INTERLEUKINE 1? - IN SERUM AND SALIVA IN PATIENTS WITH CHRONIC AUTOIMMUNE THYROIDITIS ASSOCIATING CHRONIC PERIODONTITIS � PARTICULARITIES OF EXPRESSION

Abstract

Objectives: To identify quantitative variations of serum and saliva IL-1b related to the intensity of periodontal damage in patients associating thyroid autoantibodies. Material and method: The study group included a number of 70 patients with chronic autoimmune thyroiditis (CAT), that had oral examination and are classified by the presence and severity of chronic periodontitis (CP) lesions - mild (n = 20; 20.5%), medium (n = 14; 20%), severe (n = 12; 17%) and the absence of periodontal lesions (n = 24; 34.5%). Serum and salivary levels of IL-1b (ELISA) were assessed comparatively among the patients in the four study groups. Results: There were no significant differences between the median values of serum IL-b levels (pg/ml) corresponding to the four study groups (2,44; 2,56; 1,97; 1,77) (p = 0,764), respectively the distribution of serum IL levels (pg / ml) are considered the same regardless of the presence or absence of periodontal lesions (p = 0,440). Significant differences were recorded between the median values of salivary IL levels (pg / ml) corresponding to the four studied groups (36,81; 51,22; 60,48; 21,47) (p less than 0.001, Median Test), respectively the distribution of mean values was different depending on the severity of periodontitis (p less than 0.001). Conclusions: In patients with chronic autoimmune thyroiditis there is an intensified salivary inflammatory effect with a high degree of severity depending on the degree of periodontal damage.