Analysis of Predictors of Resection and Survival in Locally Advanced Stage III Pancreatic Cancer: Does the Nature of Chemotherapy Regimen Influence Outcomes?

Author:

Bednar Filip,Zenati Mazen S.,Steve Jennifer,Winters Sharon,Ocuin Lee M.,Bahary Nathan,Hogg Melissa E.,Zeh Herbert J.,Zureikat Amer H.

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Surgery

Reference30 articles.

1. Heestand GM, Murphy JD, Lowy AM. Approach to patients with pancreatic cancer without detectable metastases. J Clin Oncol. 2015;33(16):1770–8. doi: 10.1200/JCO.2014.59.7930 .

2. Loehrer PJ, Feng Y, Cardenes H, et al. Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol. 2011;29(31):4105–12. doi: 10.1200/JCO.2011.34.8904 .

3. Chauffert B, Mornex F, Bonnetain F, et al. Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2. Ann Oncol. 2008;19(9):1592–9. doi: 10.1093/annonc/mdn281 .

4. Hammel P, Huguet F, Van Laethem J-L, et al. Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: Final results of the international phase III LAP 07 study. ASCO Meet Abstr. 2013;31(15_suppl):LBA4003. http://hwmaint.meeting.ascopubs.org/cgi/content/abstract/31/15_suppl/LBA4003 . Accessed 28 Mar 2016.

5. Mukherjee S, Hurt CN, Bridgewater J, et al. Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial. Lancet Oncol. 2013;14(4):317–26. doi: 10.1016/S1470-2045(13)70021-4 .

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