ASO Author Reflections: Which is the Optimal Preoperative Systemic Chemotherapy Regimen for Patients with Peritoneal Metastases from Colorectal Cancer?

Author:

Kepenekian Vahan,Kefleyesus Amaniel,Passot Guillaume,Rousset Pascal,Benzerdjeb Nazim,You Benoit,Peron Julien,Glehen Olivier

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Surgery

Reference5 articles.

1. Quenet F, Elias D, Roca L, et al. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(2):256–66. https://doi.org/10.1016/s1470-2045(20)30599-4.

2. Rovers KP, Simkens GA, Punt CJ, van Dieren S, Tanis PJ, de Hingh IH. Perioperative systemic therapy for resectable colorectal peritoneal metastases: Sufficient evidence for its widespread use? A critical systematic review. Crit Rev Oncol Hematol. 2017;114:53–62. https://doi.org/10.1016/j.critrevonc.2017.03.028.

3. Rovers KP, Bakkers C, Nienhuijs SW, et al. Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases. JAMA Surg. 2021;156(8):710–20. https://doi.org/10.1001/jamasurg.2021.1642.

4. Cremolini C, Antoniotti C, Stein A, et al. Individual patient data meta-analysis of FOLFOXIRI plus bevacizumab versus doublets plus bevacizumab as initial therapy of unresectable metastatic colorectal cancer. J Clin Oncol Official J Am Soc Clin Oncol. 2020;38(28):JCO2001225. https://doi.org/10.1200/jco.20.01225.

5. Fanget F, Kefleyesus A, Peron J, et al. Comparison of neoadjuvant systemic chemotherapy protocols for the curative-intent management of peritoneal metastases from colorectal cancer, regarding morphological response, pathological response, and long-term outcomes—a retrospective study. Ann Surg Oncol. 2023. https://doi.org/10.1245/s10434-023-13150-x

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