Antiseptics: analysis of assortment, technologies of compounding and using

Abstract

Proper hand hygiene disrupts the spread of a numerous infections and is therefore a guarantee of good human health. Wide use of antiseptics by the public raises questions about their effectiveness, safety and availability. At the same time, the culture of hand hygiene is a priority for all spheres of society. The aim of the work is to study the range of antiseptics on the pharmaceutical market of Ukraine and assess the peculiarities of their use, to compound the antiseptic for hands of optimal composition and provide its quality control. The study used information retrieval, pharmacological, organoleptic, physical and chemical, graphic and statistical methods. Based on the analysis of information sources, the active ingredients and their optimal concentrations in the composition of antiseptics of industrial and extemporaneous production have been established. According to the results of this stage of work, four prescriptions of antisepticswith different compositions were selected for further compounding.It was found that positive results of quality control according to the organoleptic and physical and chemical parameters were received for the solution compounded using 96%ethanol and paying attention to key technological features that are decisive in the compounding of non-aqueous solutions and affect the quality of the product. The problematic issues of registration and circulation of antiseptics in Ukraine were identified as a result of the development of normative documents. Its consequence is the spread of unscrupulous practices of selling products that do not have a proven disinfection effect. The active components of industrial and extemporaneous antiseptic agents were determined based on the analysis of literary sources. It was established that most of the products recommended for home production did not meet the requirements of regulatory documents in terms of composition and concentration of active substances. This is a sign of the spread of unreliable information among the population, which can harm health. The need to comply with the rules for dosing ingredients and the technological features of manufacturing of non-aqueous solutions is substantiated. It was established that the required concentration of ethanol in the finished product is achieved when preparing solutions according to prescription N 3, which included 96% ethanol according to the results of the physical and chemical control. The presence of disinfection corners at National Pirogov Memorial Medical University, Vinnytsya certainly popularizes hand hygiene among students of higher education. This is indicated by the high frequency of students' use of the products that were placed in the appropriate places. At the same time, it was established the need to conduct educational work among students, which will contribute to increasing the level of awareness of the regulatory framework of registered disinfectants, their proper composition, labeling and method of use.