The Relationship between Recurrent Hospitalization and Inflammation in Heart Failure Patients

Abstract

Objective: In this study, we aimed to show whether there is a relationship between inflammatory markers and recurrent hospitalizations within 1 year in patients with heart failure. Methods: All patients over the age of 18 who were followed up with a diagnosis of heart failure in the cardiology outpatient clinic between 2020-2021 were included in the study. The files of the patients were scanned and their sociodemographic characteristics, hemogram and biochemical parameters were recorded. Platelet lymphocyte ratio (P/L), neutrophil lymphocyte ratio (N/L), monocyte HDL (monocyte/HDL) ratios were calculated from inflammatory markers. It was screened how many times the patients were hospitalized and followed up in the hospital in the last year. The correlation between the number of hospitalizations and inflammatory markers were evaluated. Results: 483 patients were included in the study. The mean age of the patients was 65.65±11.75 years. The mean ejection fraction of the patients was found to be 29.53±6.102% (minimum 15 and maximum 45). CRP=8.01±9.29, monocyte HDL ratio=0.0172±0.010, platelet-lymphocyte ratio=149.24±88.80, neutrophil-lymphocyte ratio=4.54±4.88.It was determined that 73 (15.1%) of the patients had recurrent hospitalizations within one year. A significant positive correlation was found between recurrent hospitalizations and monocyte HDL ratio (r= 0.123, p=0.007), but no significant correlation was found with other parameters. Conclusion: A significant positive correlation was found between recurrent hospitalizations and only monocyte HDL ratio. No significant correlation was found between other inflammatory markers. Larger studies with a large number of cases are needed to evaluate the relationship between recurrent hospitalization and inflammation.