Contribution of Phosphodiesterase-5 (PDE5) Inhibitors in the Various Diseases

Abstract

The PDE-5 inhibitors, i.e., phosphodiesterase-5 inhibitors like sildenafil, vardenafil, and tadalafil, are the most used in premature erectile dysfunction. Many literature reviews suggest that these classes of drugs are commonly used in erectile dysfunction. Many of these reviews suggest that these inhibitors (PDE-5) are used in many other diseases apart from erectile dysfunction. So, in this review, we find the main mechanism of action of PDE-5 inhibitors in different disease conditions. These inhibitors have a major role in different diseases like erectile dysfunction, memory enhancement, cancer (cell proliferation), lower urinary tract symptoms, and pulmonary arterial hypertension. This class of drug also acts through the cGMP pathway. We found that cGMP plays an important role in different diseases like erectile dysfunction, cancer, and memory enhancement. So, in this review, we show the mechanism of PDE-5 inhibitor in different disease conditions. Keywords: PDE-5, Erectile dysfunction, Memory enhancement, cGMP, Pulmonary arterial hypertension.