Effectiveness of intrathecal dexmedetomidine versus fentanyl as additives to hyperbaric bupivacaine on postoperative analgesia in women undergoing cesarean section: a systematic review protocol

Abstract

Objective: The aim of this review is to compare the effectiveness of intrathecal dexmedetomidine to fentanyl as additives to hyperbaric bupivacaine in providing postoperative analgesia in patients undergoing cesarean section. Introduction: Pain following cesarean section remains a challenge, with limited treatment options due to potential undesirable parturient and neonatal side effects. Intrathecal dexmedetomidine has emerged as a favorable alternative to opioid additives to hyperbaric bupivacaine in prolonging postoperative analgesia, but its effectiveness still requires further investigation. Inclusion criteria: The review will evaluate studies of patients who underwent cesarean section under spinal anesthesia where dexmedetomidine and fentanyl were compared as intrathecal additives to hyperbaric bupivacaine regarding the outcome of postoperative analgesia. This review will consider randomized controlled trials, non-randomized controlled trials, and prospective cohort studies for inclusion. No limits regarding publication date or language will be applied. Methods: A preliminary search of PubMed and Cochrane Central Registry of Controlled Trials has been conducted to identify relevant index terms and keywords, which will be applied in a second search across PubMed, Cochrane Central, Scopus, and Embase. Google Scholar, National Library of Medicine (Clinicaltrials.gov), and the World Health Organization International Clinical Trial Registry Platform will be searched to identify unpublished literature. Full-text studies will be subjected to an assessment of methodological quality, and data extraction will be performed independently by 2 reviewers. The results will be presented in both tabular and narrative format and, where possible, pooled into a meta-analysis and a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) Summary of Findings. Review registration: PROSPERO CRD42022364815