Exercise Mediates Myokine Release and Tumor Suppression in Prostate Cancer Independent of Androgen Signaling

Author:

Kim Jin-Soo,Taaffe Dennis R.,Galvão Daniel A.,Saad Fred1,Newton Robert U.

Affiliation:

1. Department of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada

Abstract

A prominent toxicity of androgen suppression in patients with prostate cancer (PCa) is loss of skeletal muscle. Exercise may induce tumor suppression through the endocrinal function of skeletal muscle; however, this is currently unknown. In this review, we summarize our work demonstrating the acute and chronic myokine response to exercise and the tumor-suppressive effect of circulatory milieu alteration in PCa patients.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physical Therapy, Sports Therapy and Rehabilitation,Orthopedics and Sports Medicine

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