Development and evaluation of methotrexate nanocomposites using Β-cyclodextrins/alginate polymers and response surface methodology

Abstract

β-cyclodextrin and alginate polymers have been extensively investigated for their use in drug delivery systems. β-Cyclodextrin-alginate nanoparticles (CD/Alg) as an innovative drug carrier was the preapared by ionic chelation method. Methotrexate (MTX) as model drug was loaded onto the β-CD/Alg nanoparticles to form MTX-CD/Alg nanocomposites, via ionic interactions. The study was to investigate the changes in independent variables (concentration of CD, Alg and CaCl2) loading efficiency and particle size using 4-levels of CD, 5-levels of Alg and 4-levels of CaCl2. The Optimum nanocomposite has %LE (58.1% and particle size (213 nm). The prepared nanocomposites were chrecterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), a thermogravimetric analysis (TGA) and a release study. FTIR analysis displayed the drug into nanocomposites. The XRD pattern of MTX-β-CD/Ag nanocomposite suggested a peak at 2θ = 44.6° with the amorphous properties. A novel MTX-CD/Alg nanocomposites was developed. Optimized, characterized, and release studied was performed. These nanocomposites will be prmosing by delivering the drug in powder form