Effect of 4A zeolite on adsorption and release properties of sodium alginate/chitosan microspheres to sodium valproate

Abstract

4A zeolite/sodium alginate/chitosan microspheres (4A/SA/CS Ms) and sodium alginate/chitosan microspheres (SA/CS Ms) were prepared and its characterization were confirmed by the results of XRD, FTIR and SEM. Results showed that the addition of 4A zeolite can enlarge its particle size and is more conducive to balling. Adsorption properties of two microspheres toward sodium valproate (SV) were studied at different pH and temperature and it can be observed that the equilibrium adsorption capacity of 4A/SA/CS Ms for SV at pH = 7 was 8.1833 mg/g, compared with 4.9776 mg/g by SA/CS Ms, which reveal that 4A zeolite can increase the adsorption capacity. Cumulative release percentage reach to 42.69% in 48 hours by 4A/SA/CS@SV Ms at 25 ℃ and pH = 7 which demonstrated that 4A zeolite could improve the drug release performance. Overall, these results suggest that 4A/SA/CS Ms show a case to be used as promising drug carriers.