Biogenic selenium nanoparticles: their dual impact on spleen and growth in arthritic mice

Abstract

Selenium is known to be an important element for growth and splenic microenvironment regulation. About 5–10% of RA patients presented enlarged spleen along with low levels of selenium than the normal individuals. The current study aims to determine the effects of biogenic selenium nanoparticles (SeNPs) on the growth and spleen of healthy and arthritic mice. Biogenic SeNPs were evaluated for their adverse as well as therapeutic effects on the growth rate and splenic integrity of healthy and arthritic Balb/c mice. The tested doses of SeNPs significantly reduced the growth of mice along with splenomegaly in biosafety profiling while the treatment revealed dose-independent improvement in the growth of arthritic mice as compared to untreated arthritic control with no adverse effect on spleen. Concluding, selenium levels directly affect the growth of mice with no harm to splenic integrity in arthritic mice, however further investigation is required to develop a new method for evaluating the efficacy of Se sources.