PROGNOSTIC VALUE OF DYNAMIC THIOL-DISULFIDE HOMEOSTASIS IN PREDICTING HOSPITAL MORTALITY IN HYPOXEMIC RESPIRATORY FAILURE
-
Published:2022-05-11
Issue:
Volume:
Page:
-
ISSN:2602-3482
-
Container-title:International Journal of Health Services Research and Policy
-
language:en
-
Short-container-title:IJHSRP
Author:
İLANBEY Bilal1, ZORLU Duygu2, ÇALIŞKAN Hacı Mehmet2, ERTÜRK Zamir Kemal3, ÇELİK Burak4, ERSOY Süleyman2, GÜÇLÜ Kenan2
Affiliation:
1. KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ 2. KIRSEHIR AHI EVRAN UNIVERSITY 3. Etimesgut Sehit Sait Erturk State Hospital 4. Kırşehir Eğitim ve Araştırma Hastanesi
Abstract
Hypoxemic respiratory failure (HRF) has a PaO2 < 60 mmHg with normal or subnormal PaCO2. The gas exchange is impaired at the level of the alveolo-capillary membrane. HRF is associated with high mortality in hospital, and there is no diagnostic laboratory test to predict this mortality. This study evaluates the possibility of predicting mortality in HRF patients with dynamic thiol-disulfide homeostasis parameters, which are indicators of oxidation state. Sixty-two patients with HRF and 40 healthy controls were included in the study. Dynamic thiol-disulfide parameters were studied from the serum of all participants. Total and native thiol levels were significantly lower in the patients than in the controls (p < 0.05). Disulfide levels were higher in patients who died than survivors (p
Publisher
INESEG Yayincilik
Subject
Hardware and Architecture,Geology,Geotechnical Engineering and Engineering Geology
Reference24 articles.
1. Gurka, D. P., and Balk, R. A., "Acute respiratory failure," Critical Care Medicine, pp. 773-794: Elsevier, 2008. 2. Roussos, C., and Koutsoukou, A., “Respiratory failure”, European Respiratory Journal, 22 (47 suppl), 3s-14s, 2003. 3. Radovanovic, D., Rizzi, M., Pini, S., Saad, M., Chiumello, D. A., and Santus, P., “Helmet CPAP to treat acute hypoxemic respiratory failure in patients with COVID-19: a management strategy proposal”, Journal of clinical medicine, 9 (4), 1191, 2020. 4. Vincent, J.-L., Akça, S., De Mendonça, A., Haji-Michael, P., Sprung, C., Moreno, R., Antonelli, M., Suter, P. M., and Group, S. W., “The epidemiology of acute respiratory failure in critically ill patients”, Chest, 121 (5), 1602-1609, 2002. 5. Kelley, M. A., Manaker, S., and Finlay, G., “Predictive scoring systems in the intensive care unit”, UpToDate. Available at: URL: http://www. uptodate. com/online/content/author. do, 2012.
|
|