Affiliation:
1. Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
2. Rostov State Medical University
Abstract
Anaphylaxis is a severe, life-threatening, systemic hypersensitivity reaction that develops rapidly and can lead to death. The diagnosis of anaphylaxis continues to be primarily clinical. Therefore, a large number of studies are initiated annually aimed at a deeper study of the mechanisms of the development of this disease and the search for its biomarkers, which could become an important tool to facilitate the verification of diagnosis, prevention and risk assessment of repeated episodes of anaphylaxis, stratification of the severity of its course, the risk of life-threatening episodes of systemic reactions, and be important in the development of new therapeutic strategies. This review provides information on the currently available data on potential biomarkers of anaphylaxis.
Publisher
Rostov State Medical University
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference53 articles.
1. Cardona V, Ansotegui IJ, Ebisawa M., El-Gamal Y, Rivas MF, et al. World allergy organization anaphylaxis guidance, 2020. World Allergy Organ J. 2020;13(10):100472. DOI: 10.1016/j.waojou.2020.100472
2. Muraro A, Worm M, Alviani C, Cardona V, Dunn Galvin A, et al. EAACI guidelines: Anaphylaxis (2021 update). European Academy of Allergy and Clinical Immunology, Food Allergy, Anaphylaxis Guidelines Group. Allergy. 2022;77(2):357-377. DOI: 10.1111/all.15032
3. Rossijskaya associaciya allergologov i klinicheskih immunologov i Obshcherossijskaya obshchestvennaya organizaciya «Federaciya anesteziologov i reanimatologov». Klinicheskie rekomendacii. Anaphylactic shock. 2020. (In Russ.). Available at: https://raaci.ru/dat/pdf/allergic_shock_2020.pdf Accessed on April 16, 2022.
4. Pampura AN, Esakova NV. Anaphylaxis in children. Moscow: ID «MEDPRAKTIKA-M»; 2020. (In Russ.).
5. Beck SC, Wilding T, Buka RJ, Baretto RL, Huissoon AP, Krishna MT. Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives. Front. Immunol. 2019:10:494. DOI: 10.3389/fimmu.2019.00494