Changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis(3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process

Abstract

Objective: to evaluate changes in the activity of markers of pro/antioxidant systems of liver tissue of animals carrying melanoma B16 with the introduction of dimethyltin bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) (Me-3) at different stages of the development of the tumor process.Materials and methods: the study was conducted on mice of the C57Bl/6 line (females). 48 hours after the transplantation of tumor cells to female mice of the C57Bl/6 line, the studied compounds were administered intraperitoneally 1 time per day for 5 days according to the classical method used for screening compounds with a suspected antitumor effect. The tested compounds were administered at a total dose of 375 mg/kg. The animals were removed from the experiment on the 7th and 18th days after the transplantation of tumor cells.Results:  with the introduction of Me-3, there was a decrease in malondialdehyde as the main indicator of the activity of lipid peroxidation at all stages of the development of the tumor process.Conclusions: the multidirectional effect of Me-3 on the enzymatic activity of the antioxidant system on days 7 and 18 of the development of melanoma B16 suggests some selectivity of action depending on the initial pro/antioxidant status of the cell, as well as the expediency of studying this group of compounds as a substrate for nanozymes with pro/antioxidant activity.