Research of subchronic oral toxicity after the injection of organotin compounds containing a fragment of 2,6-di-tert-butylphenol

Abstract

Objective: to assess the subchronic  toxicity of bis(3,5-di-tert-butyl-4-hydroxyphenyl)dimethyltin (Me-3) and (3,5-di-tert-butyl-4-hydroxyphenyl)triphenyltin (Me-5) with the identification  of external signs  of toxicity and changes  in the indicators of the functional state of the liver and kidneys of Wistar rats (females) with 14-fold daily intragastric injection to simulate a metronomic  chemotherapy  regimen. Materials and method: the study was conducted  on 24 Wistar rats (females) weighing 190-210 g. The tested compounds were administered  fourteen times daily intragastrically  at a total dose of 2000 mg/kg for Me-3, 954 mg/kg for Me-5. Results: for substances belonging to the class of organic tin derivatives: the features of the toxic process and indicators of the functional  state of detoxification  organs (liver and kidneys) with subchronic administration were revealed. The injection  in total doses amounting to a half-year dose with a fourteen-fold administration did not cause the death of animals and the development  of external signs of toxicity, changes in the functional state of the liver and kidneys were not noted. Conclusion: the analysis of the results of the study will allow us to develop optimal schemes for the injection of organotin compounds containing a fragment of 2,6-di-tert-butylphenol in the metronomic regimen.