Metabolic effects of the liraglutide: a discussion of the results of clinical observations

Abstract

Objective: to discuss the features of the use of the drug liraglutide for the treatment of patients with obesity, to analyze the metabolic parameters dynamic and the difficulties that arise during therapy, based on our own clinical observations.Materials and methods: the article provides an analysis of our own clinical observations of patients aged 54 and 47 years who received liraglutide therapy for exgenous constitutional obesity of the II degree. According to the examination results, both patients showed hyperinsulinemia and insulin resistance signs, lipid metabolism disorders. There were no episodes of acute pancreatitis in the past. Heredity for medullary thyroid cancer is not burdened, thyroid status is normal. Dose liraglutide escalation is recommended on a schedule 0.6 mg per week.Results: during therapy with liraglutide, patients under observation experienced a gradual progressive decrease in body weight against the background of a decrease in appetite and a decrease in the amount of food consumed. In the dynamics, there was a tendency to normalize the initial metabolic disorders: a decrease in insulin resistance and hyperinsulinemia, carbohydrate metabolismdisorders and lipid profile.Conclusion: the results of our own clinical observations indicate the effectiveness of the drug liraglutide use in the treatment of patients with obesity, not only to achieve the target weight loss indicators, but also to correct the initial disorders of the metabolic status.