Kidney damage in patients with chronic heart failure and obesity: the role of leptin and adiponectin

Abstract

Objectives: to assess the functional state of the kidneys and cardiovascular risk in relation to the level of leptin and adiponectin in patients with chronic heart failure (CHF) and obesity.Materials and methods: a total of 116 patients with CHF of I-III functional class (FC) 45-65 years old were examined, which were divided into three comparable groups depending on body mass index (BMI).Results: a statistically significant decrease in glomerular filtration rate (GFR), a significant increase in the level of albuminuria (AC) and β2-microglobulins (β2-MG) among patients with chronic heart failure and obesity were revealed. The leptin level significantly increased from the 1st to the 3rd group, the adiponectin concentration decreased from the 1st to the 3rd group. Significant correlations were established between the concentrations of adipokines, HOMA-IR and GFR, AC, β2-MG in the group of individuals with heart failure and obesity.Conclusions: reliable deterioration of renal functional parameters in patients with CHF, statistically significant relationships between GFR, AC, β2-MG and adipokines, HOMA-IR with increasing body weight, as well as an increase in the combined risk of CKD progression and the development of cardiovascular complications with comparable FC were established.